Widely recognised as one of the most esteemed artists of his generation, In 1999, he achieved international breakthrough status when he directed the world premiere of Luciano Berio’s Cronaca del Luogo at the esteemed Salzburg Festival. Since then, he has become a frequent guest at the festival, delivering acclaimed productions such as Gluck’s Iphigenie en Tauride, Mozart’s Zaide, and the Da Ponte trilogy, which have been revived in prestigious venues across Europe and America. His work extends to other prominent opera houses, including the Bayerische Staatsoper Munich, where he directed Luisa Miller, and the Bayreuth Festival, where he directed Der fliegende Holländer in 2003. He has also made regular appearances at the Zurich Opera, impressively directing productions such as Fierrabras and Parsifal. A Wagner specialist, he has brought to success several productions of the composer’s works, including Lohengrin at Teatro alla Scala in Milan, Tannhäuser at the Wiener Staatsoper, Tristan und Isolde at Opernhaus Zürich, and the complete Ring Cycle at the Hamburg Staatsoper. Guth’s directorial accomplishments also include the highly praised production of Don Carlo, which marked the opening of the 2022/23 season at Teatro San Carlo in Naples, as well as Elektra at Oper Frankfurt and Semele at Bayerische Staatsoper in Munich. For the season 2023/24 at the Wiener Staatsoper he directed Turandot and Chowanschtschina at the Staatsoper Berlin.  At Festival d’Aix-En-Provence he created with conductor Raphaël Pichon Samson, a new work of a lost opera by Jean-Philippe Rameau. In 2025 Liebe der Danae at the Bayerische Staatsoper and Mozart’s Mitridate at Teatro Real in Madrid. In summer 2025 he was invited to direct Bluebeard’s Castle and Voix Humaine at Tiroler Festspiele Erl. Has earned the prestigious “Faust” prize on two occasions. Moreover, his production of Jenufa at the Royal Opera House was honoured with the Olivier Award for Best Production in 2022 and Bluthaus at the Bayerische Staatsoper was awarded the 2022 prize as Best International Production by the Musiktheaterpreis in Austria, and he received the Oper! Awards for Best Director in 2023.